WebApr 11, 2024 · Bromodomain and extra-terminal domain (BET) inhibitors have been shown to provide therapeutic benefits against many different cancers. However, the mechanisms governing response and resistance to ... WebAug 25, 2024 · Horikawa, N. et al. Anti-VEGF therapy resistance in ovarian cancer is caused by GM-CSF-induced myeloid-derived suppressor cell recruitment. Br. J. cancer 122, 778–788 (2024).
Drug resistance in cancer: mechanisms and tackling …
WebFeb 12, 2024 · Ferroptosis is an intracellular iron-dependent form of cell death that is distinct from apoptosis, necrosis, and autophagy. Extensive studies suggest that ferroptosis plays a pivotal role in tumor suppression, thus providing new opportunities for cancer therapy. The development of resistance to cancer therapy remains a major challenge. A number of … WebApr 14, 2024 · Sphingosine kinase 1 is a protooncogene associated with therapeutic resistance in breast cancer [164,165] and can be inhibited with the synthetic structural analog of sphingosine, Fingolimod (FTY720) [166,167]. Interestingly, FTY720 inhibits autophagy and triggers apoptosis in trastuzumab-resistant breast cancer cells . diwaka tours and travel
Emerging Nano-Based Strategies Against Drug Resistance in …
WebDrug resistance in cancer comes in two forms: intrinsic resistance and acquired resistance. Intrinsic resistance is present before a therapy is administered, and it … WebAug 16, 2024 · For instance, in triple-negative breast cancer, distinct myeloid cell profiles, including neutrophils and macrophages, mediated resistance to ICB 13 and hepatic macrophages in liver metastases ... WebAug 24, 2024 · The ability of a cancer cell to adapt to a new strategy to survive is called "genetic resistance." When researchers developed TKIs for the treatment of cancers such as non-small cell lung ... craftsman v60 chainsaw