Cryptotrione
WebJun 15, 2024 · 3.The first total synthesis of cryptotrione (1) has been achieved through substrate-controlled diastereoselective construction of the bicyclo [3.1.0]hexene framework via platinum-catalyzed enyne... WebCryptotrione ( 3 ), isolated from the Japanese cedar Cryptomeria japonica, showed activity against human oral epidermoid carcinoma KB cells. Henry N. C. Wong and Xiao-Shui Peng of the Chinese University of Hong Kong assembled the tetracyclic core 2 of 3 by the diastereoselective cyclization of the alkyne 1 ( Angew. Chem. Int. Ed. 2024, 59, 19929.
Cryptotrione
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Webof cryptotrione (1) (Supporting Information). We therefore turned our attention to cycloisomerization of C15'-β-silyloxy-1,5-enynes 12a-e as a way to generate the bicyclo[3.1.0]hexane unit for total synthesis of cryptotrione (1), expecting that the C15'-β-silyloxy group would cause substantial steric hindrance to impact WebJun 20, 2012 · An efficient stereoselective approach to the tetracyclic core of Cryptotrione, involving an asymmetric Michael addition, ring-closing metathesis, and subsequent cyclopropanation, is described. Full text links Read article at publisher's site (DOI): 10.1039/c2ob25923k References Articles referenced by this article (32)
WebAbstract. Three pivotal reactions, namely, enyne cycloisomerization, polyene cyclization, and quinone methide formation, are applied to synthesize the complex polycyclic skeleton of cryptotrione. This review summarizes the most prominent applications of these three reactions to the total syntheses of natural products, covering results published ... WebCryptotrione (1), a novel C35-terpene, was isolated from the bark of Cryptomeria japonica in 2010. On one hand, cryptotrione has an unprecedented skeleton possessing an abietane-type diterpene...
WebThe total synthesis of cryptotrione (1) was enabled by substrate‐controlled diastereoselective construction of the bicyclo[3.1.0]hexene framework through … WebThe total synthesis of cryptotrione (1) was enabled by substrate‐controlled diastereoselective construction of the bicyclo[3.1.0]hexene framework through …
WebCryptotrione (3), isolated from the Japanese cedar Cryptomeria japonica, showed activity against human oral epidermoid carcinoma KB cells. Henry N. C. Wong and Xiao-Shui Peng …
WebCryptotrione Song Chen,a Chao Rong,a Pengju Feng,a Songlei Li,a and Yian Shi*a,b a Beijing National Laboratory for Molecular Sciences, CAS Key Laboratory of Molecular Recognition … psp in telecomWebThen he spent two more years postdoctoral research in the same group, in where he finished the total synthesis of Cryptotrione, and one year in the school of pharmacy in the same university. Maoyun joined the Brown group and is now working on metal-catalyzed alkene difunctionalization. In his free time, he enjoys staying with his family, hiking ... horseshoes madingleyWebCryptotrione (1) is a complex terpenoid isolated in 2010. Now Xiao-Shui Peng (彭小水) and coworkers from the Chinese University of Hong Kong reported the racemic total synthesis … horseshoes marcrossWebRepresentative Structures of Cryptotrione Family. Our retrosynthetic analysis of the structure of cryptotrione (1) has revealed the bicyclo[3.1.0]hexane unit and quinone … horseshoes long lane menuWebAn efficient stereoselective approach to the tetracyclic core of Cryptotrione, involving an asymmetric Michael addition, ring-closing metathesis, and subsequent … horseshoes luckyWebJul 21, 2024 · The total synthesis of cryptotrione ( 1) was enabled by substrate-controlled diastereoselective construction of the bicyclo [3.1.0]hexene framework through platinum … psp in storesWebNational Center for Biotechnology Information psp in security