WebThis assay is to provide CUTLL1-based In Vitro Cell Exclusion Zone Assay (Migration) to accelerate our client's oncology projects. The assay will be customized according to the … WebCell information for CUTLL1. Find diseases associated with this biological target and compounds tested against it in bioassay experiments.

CUTLL1, a novel human T-cell lymphoma cell line with t(7;9 ...

WebApr 30, 2015 · The CUTLL1 cell line generated in our laboratory has been previously described. 9 Mouse primary tumors were cultured in vitro with OP9 stromal cells in OPTIMEM-Glutamax medium supplemented with mouse IL7 (10 ng/mL), β-mercaptoethanol (55 μM), 10% fetal bovine serum, and 1% penicillin/streptomycin for 2 weeks and then … WebInternalization of EV_miR-17-92 in dnMAM cells 89 (Fig. 1I) significantly increased the proliferation rate to a comparable level to NOTCH1-proficient 90 CUTLL1 CTRL cells (Fig. 1J). We then treated CUTLL1-wt cells with γ-secretase inhibitor (GSI; 91 see supplemental methods) and observed, as expected, a strong impairment of cell viability (Fig. the things she loved

Cross-talk between GLI transcription factors and FOXC1 promotes T-cell ...

A new cell line was established by in vitro culture of lymphoblast cells obtained from a pleural effusion sample of a 14-year-old male diagnosed with T-cell lymphoblastic lymphoma at relapse. This cell line was named CUTLL1 for Columbia University T-cell Lymphoblastic Lymphoma 1 and has been maintained in … See more Gene expression profiling with oligonucleotide microarrays showed that CUTLL1 cells have a unique gene expression signature when compared with seven other … See more Activation of NOTCH1 in T-ALL is one of several events that contributes to the multistep transformation of T-cell progenitors. Thus, activating mutations in … See more WebPubMed WebJun 6, 2011 · Furthermore, the transcription factor motifs associated with T6E cell Notch1 binding sites were the same as in CUTLL1 cells and in the same rank order: ZNF143, ETS, and RUNX. The fraction of Notch sites overlapping with each cofactor was almost identical in mouse and human ( Fig. 4 B ), and K-means clustering identified the same five classes … seth apter book