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Cyclic pifithrin-a

WebCyclic Pifithrin-α hydrobromide is a cyclic analog of pifithrin-α a small molecule inhibitor of p53. It reversibly inhibits p53-dependent transactivation of p53-responsive genes and … WebPifithrin-α (PFT-α; Item No. 13326) is a reversible inhibitor of p53-dependent transcription and apoptosis. 1 Cyclic PFT-α, also known as PFT-β, is a stable analog of PFT-α, formed by the condensation of pifithrin-α in solution. 2 It inhibits the growth of the cancer cell lines IGROV-1, A2780, and HCT116 (IC 50 = 23, 77, and 103 μM, respectively). 2,3 At doses …

Pifithrin-a - Sigma-Aldrich

WebCyclic Pifithrin-alpha Hydrobromide 98.0 %, TCI America Fisher Scientific Fisher Scientific Fisher Healthcare Fisher Science Education Sign Up for Email Help & Support … WebPifithrin-α, p-Nitro, Cyclic - CAS 60477-38-5 - Calbiochem A cell-permeable p53 inhibitor that exhibits 10-fold higher potency and 50% longer half-life than Pifithrin-α. - Find MSDS or SDS, a COA, data sheets and more information. discount kickboxing equipment https://greenswithenvy.net

Pifithrin-α alters p53 post-translational modifications ... - Nature

WebJan 23, 2024 · Interestingly, pretreatment with a p53 inhibitor (cyclic pifithrin-α) did not prevent RCX-induced apoptosis, indicating the activation of ERK1/2-mediated apoptosis in HepG2 cells by the p53 ... WebJul 17, 2024 · Cell-based assays in multiwell plates are widely used for radiosensitivity and chemosensitivity assessment with different mammalian cell types. Despite their relative ease of performance, such assays lack specificity as they do not distinguish between the cytostatic (reversible/sustained growth arrest) and cytotoxic (loss of viability) effects of … WebCyclic Pifithrin-α hydrobromide is a cyclic analog of pifithrin-α (Cat. No. 1267), a small molecule inhibitor of p53. Prevents dexamethasone-induced cell death in murine … discount kichler landscape lighting

Cyclic Pifithrin-α hydrobromide CAS:511296-88-1 P53 inhibitor ...

Category:Pifithrin-α, p-Nitro, Cyclic - CAS 60477-38-5 - Calbiochem 506154

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Cyclic pifithrin-a

Pifithrin-α =95 HPLC,powder 63208-82-2 - Sigma-Aldrich

http://shiji.cnreagent.com/s/sv253508.html WebCyclic Pifithrin-α hydrobromide is the hydrobromide salt form of Cyclic Pifithrin-α, which is a transcriptional inhibitor of p53. CAS No. 511296-88-1 Selleck's Cyclic Pifithrin-α …

Cyclic pifithrin-a

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WebPifithrin-α A cell-permeable chemical inhibitor of p53. Synonym (s): Pifithrin-α, 2- (2-Imino-4,5,6,7-tetrahydrobenzothiazol-3-yl)-1- p-tolylethanone, HBr Empirical Formula (Hill Notation): C16H18N2OS · xHBr CAS Number: 63208-82-2 Molecular Weight: 286.39 (free base basis) MDL number: MFCD00417851 WebCyclic Pifithrin-α hydrobromide has been used as p53 inhibitor to study its role in cigarette smoke−induced apoptosis of pulmonary endothelial cells. [ 1] Packaging 5, 10 mg in …

WebPifithrin-α, p-Nitro, Cyclic is a cell-permeable p53 inhibitor that exhibits 10-fold higher potency (ED50 = 30 nM in protecting etoposide-induced cortical neuron death) and 50% …

WebCyclic Pifithrin-α hydrobromide has been used as p53 inhibitor to study its role in cigarette smoke−induced apoptosis of pulmonary endothelial cells. Packaging 5, 10 mg in glass bottle Protect from light. Biochem/physiol Actions A stable analog of Pifithrin-α (Product Code P4359) with similar biological activities and lower cellular toxicity. WebPifithrin-α, p-nitro, cyclic Pifithrin-α, p-nitro, cyclic is A cell-permeable p53 inhibitor that is more potent & has a longer half-life than Pifithrin-α. 60477-38-5 sc-222177 sc-222177A sc-222177B sc-222177C : 5 mg 10 mg 25 mg 50 mg: $164.00 $300.00 $600.00 1

WebCyclic Pifithrin-α hydrobromide. Synonym(s): 2-(4-Methylphenyl)imidazo[2,1-b]-5,6,7,8-tetrahydrobenzothiazole hydrobromide, Cyclic PFT-α hydrobromide, Pifithrin-α, cyclic, QB102. Empirical Formula (Hill Notation): C 16 H 16 N 2 S · HBr. CAS No.: 511296-88-1. Molecular Weight: 349.29. Compare Product No. Description SDS Pricing; P4236:

WebCyclic Pifithrin-α hydrobromide Tocris Bioscience a Bio-Techne Brand Catalog # 3843 Citations (1) COA / SDS Catalog # Availability Size / Price Qty 797-B2-025 In Stock 25 ug / $394.00 Add To Cart Print Quote Bulk Order Key Product Details Order Information Bio-Techne Corporation tel: (800) 343-7475 (free phone) tel: (612) 379-2956 fourth of july family swimsuitsWebCyclic analog of pifithrin-α, a small molecule inhibitor of p53. Prevents dexamethasone-induced cell death in murine thymocytes (EC50= 2.01 μM). Sensitizes p53-deficient tumors to radiotherapy and chemotherapy; increases apoptosis in target cells when used in combination with antimicrotubule agents. fourth of july fb bannerWebKey features and details. Cell-permeable transcriptional p53 inhibitor. CAS Number: 60477-38-5. Purity: > 99%. Soluble in DMSO to 10 mM. Form / State: Solid. fourth of july family vacationWebPifithrin- α hydrobromide is an inhibitor of p53; reversibly blocks p53-dependent transcriptional activation and apoptosis. Protects against neuronal death in models of stroke and neurodegenerative disorders. Active in vivo; protects mice from the side-effects of cancer therapy associated with p53 induction. Supresses self-renewal of embryonic ... fourth of july family vacation ideasWebCyclic Pifithrin-α hydrobromide is a cyclic analog of pifithrin-α a small molecule inhibitor of p53. It reversibly inhibits p53-dependent transactivation of p53-responsive genes and reversibly blocks p53-mediated apoptosis, with less cytotoxicity than the parent compound. Potent STAT6 transcriptional inhibitor. fourth of july family vsgWebPifithrin-β (Synonyms: PFT β; Cyclic Pifithrin-α) Cat. No.: HY-16702 Data Sheet Handling Instructions Pifithrin-β (PFT β) is a potent p53 inhibitor with an IC50 of 23 μM. For research use only. We do not sell to patients. Pifithrin-β Chemical Structure CAS No. : 60477-34-1 * Please select Quantity before adding items. discount kid desk furnitureWebPifithrin-α, p-Nitro, Cyclic (PFN-α) is cell-permeable and active-form p53 inhibitor. Pifithrin-α, p-Nitro, Cyclic is one order magnitude more active than Pifithrin-α in protecting cortical neurons exposed to Etoposide (ED50=30 nM). Pifithrin-α, p-Nitro, Cyclic behaves as a p53 posttranscriptional activity inhibitor. Pifithrin-α, p-Nitro, Cyclic do not prevent … fourth of july films