2024 H1993 mutation

H1993 mutation

Author: vzda

August undefined, 2024

WebNCI-H1993 [H1993] is a cell line exhibiting epithelial morphology that was isolated from the lungs of a 47-year-old, White female patient with stage 3A non-small cell lung cancer: adenocarcinoma. This product has applications in cancer research. Product category Human cells Organism Homo sapiens, human Morphology epithelial Tissue Lung Disease Weband RNA-Seq data on the two cell lines allowed us to reduce a set of non-synonymous mutations to two likely drivers of oncogenesis in this patient. While 106 non …

ASCL1 is a lineage oncogene providing therapeutic targets for ... - PNAS

WebFeb 25, 2005 · The c-Met gene expression for the H1993 cells was assessed using data from the Affymetrix HG-U95Av2 gene chip. The arrays were normalized for overall intensity for hybridization and scanning. Data for the SK-LU-1 and A549 cell lines, available on both U95 and U133 chips, were used as a basis for establishing the platform to platform … http://psb.stanford.edu/psb-online/proceedings/psb14/mayba.pdf black woman in overalls

Targeting histone deacetylase enhances the therapeutic effect of ...

WebJun 17, 2014 · Experimental design: NCI-H1975 with EGFR-T790M mutation, NCI-H1993 with MET amplification and NCI-H460 with KRAS/PIK3CA mutation human NSCLC cells … WebMar 1, 2007 · Notably, a somatic intronic mutation in the Met gene has been identified recently in lung cancer, resulting in a deletion in the juxtamembrane domain and … WebApr 14, 2024 · The effect of EHE on overexpression of c-Met and EGFR in H1993 cells. The expression levels of c-Met, pMet, EGFR, and pEGFR in H1993 cells at 4 h after … fox\u0027s family double dare

Effect of Ephedra Herb on Erlotinib Resistance in c-Met

Upregulation of PD-L1 by EGFR Activation Mediates the

WebApr 12, 2024 · We previously reported that the combined application of Ephedra Herb extract (EHE) and epidermal growth factor receptor (EGFR)-tyrosine kinase inhibitor (TKI), erlotinib, is effective in suppressing the growth of erlotinib-resistant non-small-cell lung cancer (NSCLC) cell line, H1993, xenograft tumor, and cell proliferation, and that EHE … Web(A) NSCLC cell line xenograft studies using DEX sensitive cell line (NCI-H1993 in red) and resistant cell line (NCI-H2009). Once tumors for each cell line reach an average size of 150 mm3, they are randomized and split into four treatment groups (1); vehicle control (2), DEX only (3), cisplatin only and (4) DEX + cisplatin. black woman in martini glass svgWebThe preexisting carcinoma cell line mutation landscape could determine its response to particular molecular biology manipulation, such response could be inconsistent. However, only consistent results would be reported. Moreover, since genotype determined phenotype, identifying the genotype of carcinoma cell line is critical to the research result. fox\\u0027s fashion

"WebCell line H1993 was derived from the lymph nodes of a 47 year old female Caucasian with history of smoking and diagnosed with non-small cell lung cancer in 1988 (Figure 1A). After treatment with cisplatin and etoposide, H2073 was derived from the resected lung tumor of the same patient. " - H1993 mutation

H1993 mutation

Functional Expression and Mutations of c-Met and Its Therapeutic ...

Web21 rows · Genes. 660 genes mutated in the NCI-H1993 cell line from the COSMIC Cell Line Gene Mutation Profiles dataset. Show. Filter. Symbol. Name. ABCA12. ATP-binding cassette, sub-family A (ABC1), member 12. ABCA13. WebSurgically removed H1975 and H1993 tumors were homogenized and tested for levels of key glycolytic proteins (a) and subunits of mitochondrial complexes (b) by western blot analysis in response to ...

Did you know?

WebApr 3, 2024 · Background Genetic alterations, including mutation of epidermal growth factor receptor or v-Ki-ras2 kirsten rat sarcoma viral oncogene homolog and fusion of … WebJun 1, 2015 · Human NSCLC cell lines A549, PC9, HCC827, H1975, H1993, and an immortalized human lung bronchial epithelial cell line (Beas-2B) were purchased from the American Type Culture Collection. ... Peripheral blood from 20 consecutive EGFR mutation NSCLC patients before and after EGFR-TKIs treatment for 1 month was obtained in Sun …

WebMutations occur particularly in lung and colorectal cancer. Most of the somatic LKB1 mutations result in truncation of the protein. A mutational hotspot seems to be a C6 … WebApr 3, 2024 · Molecular subsets of non-small cell lung cancer (NSCLC) have been defined by various types of driver gene mutations involving epidermal growth factor receptor ( EGFR ), v-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog ( KRAS ), and anaplastic lymphoma kinase (ALK) gene fusion.

WebJan 22, 2024 · Pitavastatin and fluvastatin induced cell death in EGFR TKI resistant NSCLC cells lines A549, Calu6 and H1993 as shown by caspase 3 activation and PARP cleavage. WebFont size indicates the frequency of mutations of each gene within this model's cancer type. Variants include both germ line predisposition variants and somatic driver mutations. Where both mutations and copy number alterations are observed in the same gene, the mutations colour coding is used. ... NCI-H1993 and NCI-H2073 were derived from the ...

WebView publication. Mutation-specific primers. (A) The reverse primer specific for delE746-A750 in exon 19 (19DR3) was designed to anneal only to the genome containing a deletion of nucleotides 2235 ...

WebNational Center for Biotechnology Information black woman in profileWebMar 7, 2024 · HLA-A2-positive LUAD H1993 cells were incubated with calcein-AM (1 μm/L) for 30 min. After washing, a 1×10 5 cells/ml tumor cell suspension was prepared. Transwell 24-well plates were taken, and A and B treatment groups, positive control group, and background control group were set up. black woman in red dress clip artWebFeb 17, 2024 · Combination of ILEI knock-down and c-MET-inhibition significantly reduced the invasive outgrowth of NCI-H441 and NCI-H1993 lung tumor xenografts by inhibiting proliferation, MMP expression and E-cadherin membrane localization. ... This can be the result of a mutation that switches an oncogene on permanently or from overexpression … black woman in pajama shortsWebApr 27, 2024 · Our study demonstrated that KRAS mutation could induce PD-L1 expression through p-ERK signaling in lung adenocarcinoma. Blockade of PD-1/PD-L1 pathway may … fox\\u0027s feetWebWe previously reported that the combined application of Ephedra Herb extract (EHE) and epidermal growth factor receptor (EGFR)-tyrosine kinase inhibitor (TKI), erlotinib, is effective in suppressing the growth of erlotinib-resistant non-small-cell lung cancer (NSCLC) cell line, H1993, xenograft tumor, and cell proliferation, and that EHE … fox\\u0027s factory shopWebCancer cells derived from different stages of tumor progression may exhibit distinct biological properties, as exemplified by the paired lung cancer cell lines H1993 and H2073. While H1993 was derived from chemo-naive metastasized tumor, H2073 originated from the chemo-resistant primary tumor from t … black woman in rocking chair snow globeWebNov 7, 2024 · A549, H23, H1993, and H322M cells were obtained from the National Institutes of Health, National Cancer Institute (NCI, USA). HCC-827 and H1975 cells were obtained from the American Type Culture Collection (ATCC, USA). ... In these qPCR experiments, cell lines harboring STK11 mutations (A549, H23, and H1993) displayed > … fox\u0027s fashion